Tasmar Side Effects

Some people may experience Tasmar side effects during their treatment. However, over time, most people begin to experience significant and sometimes intolerable side effects. Some of the most common side effects of Tasmar include involuntary body movements, nausea, and sleep problems. Tasmar can also cause serious side effects that may need immediate medical care, such as a high fever, severe diarrhea, or hallucinations.

Tasmar Side Effects: An Overview

As with any medicine, side effects are possible with Tasmar® (tolcapone). If side effects do occur, they are often minor and either require no treatment or are easily treated by you or your healthcare provider. However, as with any levodopa therapy, many people will begin to experience significant and sometimes intolerable Tasmar side effects over time.
 
(This article covers many, but not all, of the possible side effects with Tasmar. Your healthcare provider can discuss a more complete list of Tasmar side effects with you.)
 

Common Tasmar Side Effects

Tasmar has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking Tasmar (along with carbidopa-levodopa) were documented and compared to side effects that occurred in another group of people taking just carbidopa-levodopa (without Tasmar). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group taking just carbidopa-levodopa.
 
In these studies, the most common side effects of Tasmar plus carbidopa-levodopa included:
 
  • Involuntary body movements (dyskinesia) -- in up to 51 percent of people
  • Nausea -- up to 35 percent
  • Sleeping problems -- up to 25 percent
  • Loss of appetite -- up to 23 percent
  • Uncontrollable, sustained muscle contractions (dystonia) -- up to 22 percent
  • Excessive dreaming -- up to 21 percent.
     
Other common side effects (occurring in 1 to 20 percent of people) included:
 
  • Muscle cramps
  • Drowsiness or fatigue
  • Diarrhea, constipation, abdominal pain (stomach pain), or vomiting
  • Headaches
  • The flu or upper respiratory tract infections, such as the common cold
  • Increased sweating
  • Dry mouth
  • Urine discoloration
  • Loss of balance
  • Gas
  • Increased muscle movements (hyperkinesia) or decreased muscle movements (hypokinesia)
  • Chest pain
  • Unusual sensations, such as burning, pricking, or tingling
  • Arthritis, stiffness, or neck pain
  • Bladder problems
  • Sinus congestion
  • Hyperactivity
  • Hair loss
  • Blood in the urine.
     
Many of these side effects are caused by carbidopa-levodopa, not by Tasmar. However, this is of little importance because Tasmar is always used in combination with carbidopa-levodopa (it is not effective at treating Parkinson's disease when used by itself). Also, because the drug increases the level of levodopa in the blood, Tasmar may increase the risk for or worsen the side effects of carbidopa-levodopa.
 
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