Stalevo Drug Interactions (Cont.)

Stalevo Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Stalevo is combined with any of the drugs listed above.
 
Antipsychotic Medications
Antipsychotics can make Stalevo less effective. Check with your healthcare provider before taking these medications together.
 
Blood Pressure Medications
Taking Stalevo and a high blood pressure medication together can increase the risk of low blood pressure (hypotension). Check with your healthcare provider, as the dose of your blood pressure medicine may need to be reduced.
 
Certain Antibiotics
Some antibiotics may affect the level of entacapone (one of the components of Stalevo) in your blood. Check with your healthcare provider before taking such medications together.
 
Cholestyramine (Prevalite, Questran, Questran Light)
Cholestyramine may affect the level of entacapone (one of the components of Stalevo) in your blood. Check with your healthcare provider before taking these medications together.
 
Iron
Iron can decrease the absorption of Stalevo into the body, perhaps making it less effective. Iron products should be taken at least two hours before or after any Stalevo dosage.
 
Isoniazid
Isoniazid can make Stalevo less effective. Check with your healthcare provider before taking these medications together.
 
Medications Metabolized by COMT
Stalevo inhibits COMT (catechol-O-methyltransferase), an enzyme that breaks down certain drugs. Stalevo could significantly increase the level of such drugs in the body, thereby increasing the risk of dangerous side effects. Check with your healthcare provider before combining Stalevo with such medications.
(Stalevo Drug Interactions Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;