Sinemet is a prescription drug commonly used in the treatment of Parkinson's disease and parkinsonism caused by encephalitis, manganese poisoning, or carbon monoxide poisoning. The medication comes in tablet form and is typically taken three or four times a day. Sinemet is not suitable for everyone and can cause bothersome and serious side effects. Common side effects include nausea, vomiting, and involuntary movements.

What Is Sinemet?

Sinemet® (carbidopa-levodopa) is a prescription medication used to treat Parkinson's disease. It is also approved to treat parkinsonism (Parkinson-like symptoms) due to encephalitis (inflammation or infection of the brain), manganese poisoning, or carbon monoxide poisoning.
(Click Sinemet Uses for more information, including possible off-label uses.)

Who Makes It?

Sinemet is made by Mylan Pharmaceuticals, Inc., for Merck & Co., Inc.

How Does Sinemet Work?

Dopamine deficiency (caused by a loss of dopamine-producing cells) in certain parts of the brain may be responsible for many of the symptoms of Parkinson's disease. Although it would make sense to give dopamine to help treat Parkinson's, this does not work, as dopamine cannot cross the blood-brain barrier. Levodopa is a precursor of dopamine, which means the body can use it to make dopamine. Unlike dopamine, levodopa crosses the blood-brain barrier.
Levodopa is almost always given in combination with carbidopa. Carbidopa delays the conversion of levodopa into dopamine until it reaches the brain, preventing or diminishing some of the side effects that often accompany levodopa therapy. Carbidopa also reduces the amount of levodopa needed for Parkinson's disease treatment.
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Sinemet Medication Information

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