Sinemet Dosage

The recommended Sinemet dosage will be based on several factors, such as how you respond to the drug, other medical conditions you have, and other medications you are taking. Sinemet comes in tablet form and is usually taken three or four times a day. In most cases, people start with a Sinemet dose of 25-100 mg three times daily.

Sinemet Dosage: An Introduction

The dose of Sinemet® (carbidopa-levodopa) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How you respond to Sinemet (especially if you develop bothersome side effects)
  • Other medications you are taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Sinemet Dosage for Parkinson's Disease

There is no standard Sinemet dosage that will work for all people. Instead, the dose must be individualized. Typically, people start with a dose of Sinemet 25-100 mg (25 mg of carbidopa and 100 mg of levodopa) three times daily. Your healthcare provider will probably recommend gradual increases the dose (usually by one tablet every day or every other day) until a dose of eight Sinemet 25-100 mg tablets are taken per day (usually as two tablets four times a day). However, you may require more or less Sinemet, and you may need more or less of the individual components.
 
Sinemet comes in three different strengths that are designed to allow some flexibility in dosing the individual components of the drug. These strengths include:
 
  • Sinemet 10-100 mg (10 mg of carbidopa and 100 mg of levodopa)
  • Sinemet 25-100 mg (25 mg of carbidopa and 100 mg of levodopa)
  • Sinemet 25-250 mg (25 mg of carbidopa and 250 mg of levodopa).
     
Most people need at least 70 mg to 100 mg of carbidopa a day in order to avoid severe nausea and vomiting due to the levodopa component of Sinemet. Doses that provide less than 70 mg of carbidopa per day are likely to cause severe nausea and vomiting.
 
Do not stop taking Sinemet suddenly, as a serious group of side effects, known as neuroleptic malignant syndrome (NMS), may occur. Symptoms of NMS include:
 
  • A high fever
  • Stiff muscles
  • Confusion
  • Irregular pulse or blood pressure
  • A fast heart rate (tachycardia)
  • Sweating
  • Irregular heart rhythms (arrhythmias).
     
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Sinemet Medication Information

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