Sinemet CR Dosage

Your Sinemet CR dosage will be determined based on several factors, such as your previous dose of immediate-release Sinemet (if you were taking it), whether you develop bothersome side effects with the medication, other existing medical conditions you have, and other medications you are taking. Do not suddenly stop taking Sinemet CR, as it may cause a serious group of side effects, known as neuroleptic malignant syndrome (NMS).

Sinemet CR Dosage: An Introduction

The dose of Sinemet® CR (carbidopa-levodopa CR) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Your previous dose of immediate-release Sinemet (if you were taking it)
  • How you respond to Sinemet CR (especially if you develop bothersome side effects)
  • Other medications you are taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Sinemet CR Dosage for Parkinson's Disease

There is no one particular Sinemet CR dosage that will work for all people. Instead, the dose must be individualized. Almost all people who start Sinemet CR are switching from immediate-release Sinemet. When switching from one to the other, it is very important to understand that the two products are absorbed differently in the body (Sinemet CR is not absorbed as well as regular Sinemet). Refer to the following chart for the recommended starting Sinemet CR dosage based on the levodopa content of your previous Sinemet dosage:
 
Previous Sinemet Dose (levodopa content)
Recommended Sinemet CR Dose (levodopa content)
300 to 400 mg per day
200 mg twice daily
500 to 600 mg per day
300 mg twice daily or 200 mg three times daily
700 to 800 mg per day
800 mg per day, split into three or more smaller doses (such as 300 mg in the morning, 300 mg in early evening, and 200 mg in the late evening)
900 to 1000 mg per day
1000 mg per day, split into three or more smaller doses (such as 400 mg in the morning, 400 mg in the early evening, and 200 mg in the late evening)

 

Sinemet CR comes in the following strengths:
 
  • Sinemet CR 25-100 mg (25 mg of carbidopa and 100 mg of levodopa)
  • Sinemet CR 50-200 mg (50 mg of carbidopa and 200 mg of levodopa).
     
Most people need at least 70 mg to 100 mg of the carbidopa component per day in order to avoid severe nausea and vomiting due to the levodopa component of Sinemet CR. Doses that provide less than 70 mg of carbidopa per day are very likely to cause severe nausea and vomiting.
 
Do not suddenly stop taking Sinemet CR, as a serious group of side effects known as neuroleptic malignant syndrome (NMS) may occur. Symptoms of NMS include:
 
  • High fever
  • Stiff muscles
  • Confusion
  • Irregular pulse or blood pressure
  • Fast heart rate (tachycardia)
  • Sweating
  • Irregular heart rhythms (arrhythmias).
     
The Dirty, Messy Part of BPH

Sinemet CR Drug Information

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