What If I Take an Overdose?

People who take too much selegiline may experience symptoms such as:
  • Drowsiness
  • Dizziness or feeling faint
  • Irritability, hyperactivity, or agitation
  • Severe headaches
  • Hallucinations
  • Lockjaw
  • A rigid, arched back
  • Seizures
  • Coma
  • A rapid and irregular pulse
  • High blood pressure (hypertension) or low blood pressure (hypotension)
  • Chest pain
  • Difficulty breathing
  • Fever, sweating, and cool, clammy skin.
(Click Eldepryl Overdose for more information.)

How Should It Be Stored?

Selegiline capsules should be stored at room temperature, away from moisture, heat, and light. Keep selegiline and all other medications out of the reach of children.

What Should I Do If I Miss a Dose?

If you forget to take a dose of selegiline, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of the medication.

How Does Selegiline Work?

Selegiline belongs to a class of medications called monoamine oxidase inhibitors (MAOIs).
A dopamine deficiency (caused by a loss of dopamine-producing cells) in certain parts of the brain may be responsible for many of the symptoms of Parkinson's disease. An enzyme called monoamine oxidase (MAO) breaks down monoamine chemicals, including dopamine. By inhibiting MAO enzymes, selegiline helps to increase the amount of dopamine that the brain can use, helping to relieve the symptoms of Parkinson's disease.
There are two types of MAO (type A and B). MAO-B is the main form in the brain and is also found in blood platelets. Although there is some MAO-A in the brain, it is found primarily in the digestive tract. MAO-A is responsible for breaking down dietary tyramine, an amino acid that affects blood pressure. Any medication that inhibits MAO-A stops the body's ability to break down tyramine and can cause a person's tyramine levels to become too high (which can be extremely dangerous). Although selegiline is "selective" for MAO-B, it can inhibit MAO-A to some extent (especially at higher doses).
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