Drug Interactions With Selegiline

There are a number of medicines that may cause negative drug interactions with selegiline, including antidepressants, stimulants, and cough medications. Some of these interactions can increase your risk of dangerous side effects, such as high blood pressure, seizures, or other problems. If drug interactions with selegiline are a concern, talk to your healthcare provider before starting any other medications.

 

Drug Interactions With Selegiline: An Overview

Selegiline hydrochloride (Eldepryl®) can potentially interact with many medicines. Because there are so many selegiline drug interactions that are extremely dangerous, it is important to check with your healthcare provider before taking any medication, including prescription and non-prescription medications. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking selegiline. Some of the medicines that may lead to selegiline interactions include:
 

 

    • Dextromethorphan (Robitussin DM® and many others)
    • Naphazoline (various nasal and eye drops, such as Visine-A®)
    • Oxymetazoline (various nasal and eye drops, such as Afrin®)
    • Phenylephrine (Sudafed PE® and many others)
    • Propylhexedrine (Benzedrex®)
    • Pseudoephedrine (Sudafed® and many others)

 

  • Meperidine (Demerol®)
  • Methadone (Dolophine®, Methadose®)
  • Mirtazapine (Remeron®)
  • Other monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Propoxyphene medications (Balacet™, Darvon®, Darvocet®)
  • "Pressor" medications, including:

 

    • Dopamine
    • Ephedrine
    • Epinephrine (Adrenalin®, EpiPen®)
    • Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
    • Levonordefrin (Carbocaine with Neo-Cobefrin®)
    • Midodrine (Orvaten®, ProAmatine®)
    • Norepinephrine (Levophed®)

 

 

 

  • Stimulants, such as:

 

 

 

 

(Drug Interactions With Selegiline Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;