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Drug Interactions With Selegiline
There are a number of medicines that may cause negative drug interactions with selegiline, including antidepressants, stimulants, and cough medications. Some of these interactions can increase your risk of dangerous side effects, such as high blood pressure, seizures, or other problems. If drug interactions with selegiline are a concern, talk to your healthcare provider before starting any other medications.
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Drug Interactions With Selegiline: An Overview
Selegiline hydrochloride (Eldepryl®) can potentially interact with many medicines. Because there are so many selegiline drug interactions that are extremely dangerous, it is important to check with your healthcare provider before taking any medication, including prescription and non-prescription medications.
Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking selegiline. Some of the medicines that may lead to selegiline interactions include:
- Apraclonidine (Iopidine®)
- Atomoxetine (Strattera®)
- Brimonidine (Alphagan® P, Combigan™)
- Buspirone (BuSpar®)
- Cyclobenzaprine (Flexeril®)
- Entacapone (Comtan®, Stalevo®)
- Levodopa medications (Parcopa®, Sinemet®, Sinemet® CR, Stalevo®)
- Many cough, cold, and allergy products, such as:
- Dextromethorphan (Robitussin DM® and many others)
- Naphazoline (various nasal and eye drops, such as Visine-A®)
- Oxymetazoline (various nasal and eye drops, such as Afrin®)
- Phenylephrine (Sudafed PE® and many others)
- Propylhexedrine (Benzedrex®)
- Pseudoephedrine (Sudafed® and many others)
- Meperidine (Demerol®)
- Methadone (Dolophine®, Methadose®)
- Miscellaneous antidepressants, such as:
- Bupropion (Aplenzin™, Budeprion XL®, Budeprion™ SR, Buproban®, Forfivo™ XL, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin®, Zyban®)
- Mirtazapine (Remeron®)
- Nefazodone (Serzone®)
- Trazodone (Desyrel®) or trazodone ER (Oleptro™)
- Vilazodone (Viibryd™)
- Other monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Other forms of selegiline hydrochloride (Eldepryl®, Emsam®)
- Tranylcypromine (Parnate®)
- Propoxyphene medications (Balacet™, Darvon®, Darvocet®)
- "Pressor" medications, including:
- Dopamine
- Ephedrine
- Epinephrine (Adrenalin®, EpiPen®)
- Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
- Levonordefrin (Carbocaine with Neo-Cobefrin®)
- Midodrine (Orvaten®, ProAmatine®)
- Norepinephrine (Levophed®)
- Sibutramine (Meridia®)
- SSRI or SNRI antidepressants, including:
- Citalopram (Celexa®)
- Duloxetine (Cymbalta®)
- Desvenlafaxine (Pristiq™)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®)
- Fluvoxamine (Luvox®, Luvox® CR)
- Paroxetine (Paxil®, Paxil CR®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- Stimulants, such as:
- Amphetamine and dextroamphetamine (Adderall®, Adderall XR®)
- Benzphetamine (Didrex®)
- Dexmethylphenidate (Focalin®, Focalin XR®)
- Dextroamphetamine (Dexedrine®, Dexedrine Spansules®)
- Methamphetamine (Desoxyn®)
- Methylphenidate (Concerta®, Daytrana®, Metadate CD®, Metadate ER®, Methylin®, Ritalin®, Ritalin LA®, Ritalin SR®)
- Phentermine (Adipex-P®, Ionamin®)
- St. John's wort
- Tolcapone (Tasmar®)
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amitriptyline and chlordiazepoxide (Limbitrol®)
- Amitriptyline and perphenazine (Etrafon®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®)
- Imipramine (Tofranil®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD