Drug Interactions With Selegiline

St. John's Wort
Do not take selegiline with St. John's wort (an herbal supplement), due to the risk of dangerous side effects.
 
Stimulants
Do not take stimulants and selegiline within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Tolcapone (Tasmar)
Combining tolcapone and selegiline can lead to dangerous side effects. If your healthcare provider recommends that you take tolcapone with selegiline, you may need to be monitored closely.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
You should not take tramadol while taking selegiline (or even if you have taken selegiline within the past 14 days), due to the risk of dangerous side effects.
 
Tricyclic Antidepressants
Do not take tricyclic antidepressants and selegiline within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure or seizures.
 
Tryptophan
Tryptophan and selegiline should not be taken within two weeks of each other, due to the risk of dangerous side effects, such as confusion or agitation.
 

Final Thoughts on Drug Interactions With Selegiline

Not every selegiline drug interaction was discussed in this article. There are numerous other drug interactions with selegiline, many of which are serious. Therefore, you should always talk with your pharmacist or healthcare provider about the specific drug interactions with selegiline that may apply to your situation. If you are taking selegiline (or have just stopped taking selegiline), always check with your healthcare provider before taking any prescription medication or over-the-counter products.
 
The Dirty, Messy Part of BPH

Selegiline Hydrochloride (HCl) Information

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