Drug Interactions With Selegiline

Meperidine (Demerol)
You should not take meperidine while taking selegiline (or even if you have taken selegiline within the past 14 days), due to the risk of dangerous side effects.
 
Methadone (Dolophine, Methadose)
You should not take methadone while taking selegiline (or even if you have taken selegiline within the past 14 days), due to the risk of dangerous side effects.
 
Miscellaneous Antidepressants
You should not take certain antidepressants while taking selegiline (or even if you have taken selegiline within the past 14 days), due to the risk of dangerous side effects.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking selegiline with other MAOIs can increase your chance of developing dangerous side effects. Do not take selegiline and other MAOIs within two weeks of each other.
 
Pressors
Do not take pressors and selegiline within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Propoxyphene Medications (Balacet, Darvon, Darvocet)
You should not take propoxyphene while taking selegiline (or even if you have taken selegiline within the past 14 days), due to the risk of dangerous side effects.
 
Sibutramine (Meridia)
You should not take sibutramine and selegiline within 14 days of each other, due to the risk of dangerous side effects.
 
SSRI or SNRI Antidepressants
Do not take selegiline and an SSRI or SNRI together, due to the risk of serious side effects. Because certain SSRIs or SNRIs can stay in your body for quite a while, make sure to ask your healthcare provider when you can start taking an SSRI or SNRI after stopping selegiline (or the other way around).
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