Precautions and Warnings With Procyclidine

There are several precautions and warnings with procyclidine to be aware of before starting this medication. These precautions relate to topics such as pregnancy risks, drug interactions, and potential side effects. Precautions and warnings with procyclidine also apply to people who have certain allergies or who have certain health conditions (such as glaucoma, a rapid heart rate, or difficulty passing urine).

Procyclidine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking procyclidine hydrochloride (Kemadrin®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Procyclidine

Some of the warnings and precautions to be aware of prior to taking procyclidine include the following:
  • Procyclidine can cause drowsiness, confusion, or other mental problems that may interfere with your ability to drive or operate heavy machinery.
  • Procyclidine can inhibit the body's ability to cool itself by sweating. This can lead to heat stroke, especially in hot weather. People with alcohol problems and people who work in the heat may be especially prone to heat stroke. Let your healthcare provider know if you think this may be a problem for you (as it can be quite dangerous).
  • Procyclidine can worsen (or even cause) glaucoma, bladder or prostate problems, or a rapid heart rate. If you have such problems, procyclidine may not be right for you.
  • Procyclidine should never be used to treat tardive dyskinesia. Not only is procyclidine ineffective for this use, it can actually make this condition worse.
  • Occasionally, procyclidine may worsen psychotic disorders. If you are using procyclidine to treat side effects of antipsychotic medications, your healthcare provider should monitor you closely to make sure that procyclidine does not worsen your disorder.
  • Procyclidine can cause hallucinations (seeing, hearing, or feeling things that are not really there) or other psychological problems, especially in older individuals. Let your healthcare provider know if you develop hallucinations while taking procyclidine.
  • Procyclidine can cause confusion, memory loss, or other Alzheimer's-like symptoms.
  • Procyclidine can potentially interact with several medications (see Drug Interactions With Procyclidine).
  • Procyclidine is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Kemadrin and Pregnancy).
  • It is not known if procyclidine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Kemadrin and Breastfeeding).
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