Drug Interactions With Procyclidine

Procyclidine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when procyclidine is combined with any of the drugs listed above.
 
Acetylcholinesterase Inhibitor Medications
Taking procyclidine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring.
 
Antipsychotics
Combining procyclidine with antipsychotic medications can increase the risk of certain side effects, such as an intestinal blockage or heat stroke. When using such medications together, make sure to watch for any signs of an intestinal blockage (especially severe constipation) or heat stroke. Also, procyclidine may occasionally make antipsychotic medications less effective.
 
Other Anticholinergic Drugs
Combining an anticholinergic medication with procyclidine (which is also an anticholinergic medication) can increase your risk of procyclidine side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
 
Pramlintide
Both pramlintide and anticholinergic medications (including procyclidine) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.
 
Tricyclic Antidepressants
Combining procyclidine with a tricyclic antidepressant can increase the risk of certain side effects, such as an intestinal blockage or heat stroke. When using such medications together, make sure to watch for any signs of an intestinal blockage (especially severe constipation) or heat stroke.
 
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Procyclidine HCL Drug Information

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