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Drug Interactions With Pramipexole
Certain drug interactions with pramipexole may increase your risk of side effects or cause your body to metabolize the drug differently than intended. Therefore, it is important that your healthcare provider be aware of any other medications you are taking. Substances that can cause potentially negative drug interactions with pramipexole include alcohol, antipsychotics, and medications that contain levodopa.
Pramipexole dihydrochloride (Mirapex®) can potentially interact with several different medications. Some of the medicines that may lead to drug interactions with pramipexole include:
- Alcohol
- Antipsychotics
- Cimetidine (Tagamet®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Medications that contain levodopa (Parcopa®, Sinemet®, Sinemet® CR, Stalevo®)
- Metoclopramide (Reglan®)
- Quinidine
- Quinine
- Ranitidine (Zantac®)
- Triamterene (Dyrenium®) or triamterene/HCTZ (Dyazide®, Maxzide®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®).
The following sections explain in detail the potentially negative interactions that can occur when pramipexole is combined with any of the drugs listed above.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD