Drug Interactions With Pramipexole

Alcohol
You should avoid alcohol while taking pramipexole. Combining the two can increase the risk of falling asleep during the day without warning, which can be serious, especially if you are driving or operating heavy machinery.
 
Antipsychotics
Antipsychotic medications can make pramipexole less effective. Check with your healthcare provider before taking pramipexole with an antipsychotic medication.
 
Cimetidine (Tagamet)
Cimetidine can affect the way your kidneys remove pramipexole from the body, possibly increasing the levels of pramipexole in your blood and increasing your risk of side effects of pramipexole. Do not use these medications together without your healthcare provider's approval and supervision.
 
Diltiazem
Diltiazem can affect the way your kidneys remove pramipexole from the body, possibly increasing the levels of pramipexole in your blood and increasing your risk of side effects. Do not use these medications together without your healthcare provider's approval and supervision.
 
Medications That Contain Levodopa
Levodopa is one of the most commonly used medications for treating Parkinson's disease. Many (if not most) people who take pramipexole with levodopa will need a lower dosage of levodopa, especially if levodopa side effects develop or become worse. Make sure your healthcare provider takes this into consideration.
 
Metoclopramide (Reglan)
Metoclopramide can make pramipexole less effective. Check with your healthcare provider before taking these medications together.
 
Quinidine
Quinidine can affect the way your kidneys remove pramipexole from the body, possibly increasing the levels of pramipexole in your blood and increasing your risk of side effects. Do not use these medications together without your healthcare provider's approval and supervision.
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