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Parcopa Drug Interactions
Certain Parcopa drug interactions may cause your body to metabolize the medicines differently than intended, possibly increasing your risk of side effects or decreasing the effectiveness of the medications. Some of the medications that may interact with Parcopa include antipsychotics, blood pressure medications, and iron (including many multivitamins). To avoid these problems, talk to your healthcare provider about possible drug interactions with Parcopa that may apply to you.
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Parcopa® (orally disintegrating carbidopa-levodopa) can potentially interact with many other medications. Some of the medicines that may lead to Parcopa drug interactions include:
- Antipsychotic medications (which are sometimes used for non-psychiatric uses), such as:
- Aripiprazole (Abilify®)
- Asenapine (Saphris®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Iloperidone (Fanapt®)
- Loxapine (Adasuve™, Loxitane®)
- Lurasidone (Latuda®)
- Molindone (Moban®)
- Olanzapine (Zyprexa®, Symbyax®)
- Paliperidone (Invega®)
- Perphenazine (Trilafon®)
- Pimozide (Orap®)
- Prochlorperazine (Compazine®, Compro®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Blood pressure medications
- Iron products, including many multivitamins
- Isoniazid
- Metoclopramide (Reglan®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Phenytoin (Dilantin®, Phenytek®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD