Parkinsons Disease Home > Side Effects of Pramipexole

Common Side Effects of Pramipexole

Pramipexole has been studied thoroughly in clinical trials. In these studies, one group of people received the real medication, while another group was given a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group who took the placebo.
In these studies, the most common side effects of pramipexole for Parkinson's disease treatment included:
  • Low blood pressure when suddenly standing or sitting up -- in up to 53 percent of people
  • Involuntary body movements, such as tics -- up to 47 percent
  • Nausea -- up to 28 percent
  • Insomnia -- up to 27 percent
  • Dizziness -- up to 26 percent
  • Drowsiness -- up to 22 percent
  • Weakness -- up to 14 percent
  • Abnormal dreams -- up to 11 percent.
Many people in these studies were also taking other Parkinson's medications, which likely contributed to some of these side effects.
In studies of pramipexole for restless legs syndrome (RLS), common side effects included:
  • Nausea -- in up to 27 percent of people
  • Headaches -- up to 16 percent
  • Insomnia -- up to 13 percent.

Less Common Side Effects of Pramipexole

Rare side effects of pramipexole occurred in 10 percent or less of people taking the drug. Because these side effects are so uncommon, it can be difficult to tell whether they are caused by pramipexole or something else.
These less common side effects include but are not limited to:
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Last reviewed by: Kristi Monson, PharmD;
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