Parkinsons Disease Home > Comtan and Breastfeeding

In studies on Comtan (entacapone) and breastfeeding, the drug passed through breast milk when given to rats. It is not known whether this is also true for humans, but based on the chemical properties of the drug, it is likely to pass through breast milk in women as well. Before taking Comtan, breastfeeding women should ask their healthcare providers about potential risks.

Comtan and Breastfeeding: An Overview

It is not known whether Comtan® (entacapone) is safe for use during breastfeeding, as it is not clear if the drug passes through breast milk in humans. Therefore, you should talk with your healthcare provider before taking Comtan if you are breastfeeding or plan to start.

Can I Take Comtan While Breastfeeding?

Studies have shown that entacapone (a component of Comtan) passes through breast milk in rats, but it is not known whether the same is true for humans. However, based on the chemical properties of Comtan, it is likely that it passes through breast milk in humans.
It should be noted that Comtan is always used in combination with two other Parkinson's medications: carbidopa and levodopa. Studies have shown that levodopa passes through breast milk in humans. Levodopa can also decrease the level of prolactin in the mother, a hormone that is important for breastfeeding. Theoretically, levodopa may negatively affect a woman's ability to breastfeed successfully.

Talking With Your Healthcare Provider About Comtan and Breastfeeding

You should talk with your healthcare provider about Comtan and breastfeeding. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision about Comtan and breastfeeding that is right for you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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