Parkinsons Disease Home > Artane

Artane is a prescription drug that is licensed for the treatment of Parkinson's disease (and other similar conditions) and extrapyramidal symptoms caused by antipsychotic medications. It works by blocking the effects of acetylcholine, a signaling chemical in the nervous system. The medication comes in tablet and elixir form, and is available in several different strengths. Potential side effects include blurred vision, constipation, and dry mouth.

What Is Artane?

Artane® (trihexyphenidyl hydrochloride) is a prescription medication approved for treating the following conditions:
(Click Artane Uses for more information, including possible off-label uses.)

Who Makes It?

Brand-name Artane was made by Lederle Pharmaceuticals but is no longer available. Generic Artane is made by various manufacturers (see Generic Artane for more information).

How Does It Work?

Artane is known as an anticholinergic medication. It works by blocking the effects of acetylcholine, a neurotransmitter (a signaling chemical in the nervous system). Normal muscle movement control requires a precise balance between acetylcholine and dopamine (another neurotransmitter). In Parkinson's disease (and with extrapyramidal symptoms caused by antipsychotic medications), dopamine levels are decreased, creating an imbalance between dopamine and acetylcholine. By blocking the effects of acetylcholine, Artane helps to re-establish a normal balance between dopamine and acetylcholine.
Although Artane also has antihistamine effects, these effects are not thought to be important for treating Parkinson's disease or extrapyramidal symptoms.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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