Lodosyn Side Effects

If you were to just take Lodosyn, side effects would be unlikely to occur. However, the medication is always taken together with levodopa, a drug that can cause side effects. Cough, nausea, and headache are some of the potential side effects that may occur with Lodosyn (in combination with levodopa). Serious levodopa and Lodosyn side effects that require immediate medical attention include fainting, heart attack, and seizures.

Side Effects of Lodosyn: An Overview

Lodosyn® (carbidopa) does not cause significant side effects when used alone. However, it is always used in combination with levodopa products (such as Sinemet®, Sinemet® CR, Parcopa®, or Stalevo®). The combination of Lodosyn with levodopa (as well as levodopa alone) can cause side effects. However, not everyone who takes the drugs will experience side effects. Many people tolerate them relatively well, at least initially. If side effects do occur, they are often minor and either require no treatment or can easily be treated by you or your healthcare provider. However, many people will begin to experience significant and sometimes intolerable side effects after several years of use.
(This article covers many, but not all, of the possible side effects with Lodosyn. Your healthcare provider can discuss a more complete list of side effects with you.)

Bothersome Lodosyn Side Effects

Although Lodosyn in combination with levodopa can cause some serious side effects, many side effects are merely bothersome, usually not dangerous, and often require no treatment. Such side effects include:
  • Dry mouth, taste changes, or drooling
  • Shoulder, leg, or back pain
  • Muscle cramps
  • Drowsiness or insomnia
  • Nausea and vomiting
  • Abdominal pain (stomach pain), diarrhea, or constipation
  • General weakness or fatigue
  • Increased sweating or dark (red, brown, or black) saliva, sweat, or urine
  • Loss of appetite, weight loss, or weight gain
  • Indigestion or heartburn
  • Headaches
  • Increased sex drive (libido)
  • Hair loss
  • Gas or hiccups
  • Teeth grinding
  • Urinary tract infection (UTI, such as a bladder infection)
  • Cough
  • Flushing or hot flashes.
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