Drug Interactions With Bromocriptine

Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when bromocriptine is combined with any of the drugs listed above.
Combining bromocriptine with an antipsychotic medication could make both medications less effective (since they work in opposite ways). In general, bromocriptine should not be used in combination with an antipsychotic medication.
Certain Antidepressants
Taking bromocriptine with certain depression medications, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome.
These symptoms can include:
  • Confusion
  • Hallucinations
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.


Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.

Bromocriptine may affect the way the body handles chloramphenicol, possibly increasing the risk of side effects of chloramphenicol. Check with your healthcare provider before taking these medications together.
CYP 3A4 Inhibitors
Bromocriptine is metabolized by a specific liver enzyme known as CYP 3A4. Some other medications (known as CYP 3A4 inhibitors) slow down the activity of this enzyme, causing an increase in the level of bromocriptine in the blood. This could potentially lead to serious bromocriptine side effects. Check with your healthcare provider before combining bromocriptine with a CYP 3A4 inhibitor.
Ergot Medications
Taking bromocriptine with other ergot medications can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. It is not recommended to take bromocriptine in combination with any other ergot medications.
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