Apokyn Warnings and Precautions

Specific Apokyn Warnings and Precautions

Some of the warnings and precautions to be aware of prior to taking Apokyn include the following:
  • Apokyn should never be injected into a vein, as this can cause blood clots.
  • Apokyn almost always causes severe nausea and vomiting. In order to avoid this problem, your healthcare provider should put you on trimethobenzamide (Tigan®), starting three days before your first dose of Apokyn and continuing for at least two months. While some people may eventually be able to stop taking trimethobenzamide, many will need to continue the medication as long as they take Apokyn.
  • Apokyn may increase the risk of a dangerous arrhythmia known as QT prolongation. Low blood potassium or magnesium levels, a slow heart rate, certain medications (known as QT-prolonging medications), and certain heart problems can increase the risk of QT prolongation.
  • Apokyn can cause dangerously low blood pressure (hypotension). In order to help prevent this problem, your first dose of Apokyn (a "test dose") should be taken under the supervision of your healthcare provider, who will monitor your blood pressure for at least an hour after the dose. Let your healthcare provider know if you develop signs of low blood pressure, such as dizziness, lightheadedness, or fainting.
  • Apokyn can cause falling, often due to low blood pressure or fainting. Let your healthcare provider know if you have any falls (serious or not) while taking Apokyn.
  • Apokyn can cause hallucinations (seeing, hearing, feeling, smelling, or even tasting things that are not really there). This is not a rare Apokyn side effect, as it occurs in up to 14 percent of people taking the medication.


  • Mental or behavioral changes have been reported with Apokyn, particularly after starting the drug or increasing the dose. Sometimes, these changes can be very severe (including psychotic-like behavior). As a general rule, people who already have a psychotic disorder should not be treated with this drug. 


  • There have been reports of people falling asleep unexpectedly during daily activities while taking Apokyn. It may be a good idea to avoid driving or operating heavy machinery until you know how Apokyn will affect you.
  • Apokyn may increase the risk of heart problems, such as heart attacks, chest pain, or cardiac arrest. It is thought that these effects are due to low blood pressure (as very low blood pressure can deprive the heart of oxygen).
  • Injection site reactions (such as bruising or itching at the site of the injection) are common with Apokyn.
  • Apokyn contains sodium metabisulfite, a sulfite product. Do not take Apokyn if you are allergic to sulfites. People with asthma may have a higher risk for sulfite allergies.
  • Rarely, there have been reports of people abusing Apokyn, usually for its sexually stimulating effects. If you feel the urge to use Apokyn inappropriately, please discuss this with your healthcare provider.
  • Apokyn can cause (or worsen) dyskinesias, which are uncontrollable muscle movements.
  • Seek immediate medical attention if you have a painful penile erection that does not go away (this is known medically as priapism). Delaying treatment for this problem can lead to permanent damage (which can cause impotence).
  • If you have liver or kidney disease, a lower Apokyn dosage may be recommended. In some cases, Apokyn may not be a good choice for you.
  • In animal studies, Apokyn caused retinal (eye) problems in rats. It is not known if the same problem can occur in humans.
  • Apokyn can potentially interact with several medications (see Apokyn Drug Interactions).
  • Apokyn is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Apokyn and Pregnancy).
  • It is not known if Apokyn passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Apokyn and Breastfeeding).
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