Precautions and Warnings With Amantadine

Talk to your healthcare provider about precautions and warnings with amantadine before starting treatment to discuss possible side effects or complications that may occur. You should also tell him or her if you have glaucoma, epilepsy, or kidney or liver problems, as they may become worse with amantadine. Safety concerns also include potential drug interactions and allergic reactions.

Amantadine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking amantadine hydrochloride (Symmetrel®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Amantadine

Some of the warnings and precautions to be aware of prior to taking amantadine include the following:
  • An amantadine overdose can be dangerous. Deaths have occurred from both intentional and unintentional overdoses.
  • People have attempted suicide while taking the drug. This may be more likely to occur in people who have a psychiatric disorder or a history of substance abuse. It may also be related to some of the unusual amantadine side effects, such as agitation, hallucinations, depression, or anxiety.
  • Amantadine may make congestive heart failure (CHF) worse or may actually cause it. Check with your healthcare provider before taking the drug if you have CHF or swelling in the hands, feet, or ankles (as this can be a sign of CHF).
  • The medication may worsen untreated acute angle-closure glaucoma (an eye condition).
  • People with Parkinson's disease should not suddenly stop taking amantadine, as serious problems could occur.
  • The medication may increase the risk of seizures in people who have epilepsy or seizure disorders. If you have either of these conditions, check with your healthcare provider before taking amantadine.
  • Amantadine can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:
    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • An irregular heart rhythm (arrhythmia).
Tell your healthcare provider right away if you think you might have NMS.
  • If you have kidney or liver problems, your body may not handle amantadine as well as it should. You may need a lower amantadine dosage and, in some cases, the drug may not be recommended.
  • Do not drive or operate heavy machinery until you know exactly how amantadine affects you.
  • Intense, unusual urges have been reported in people taking Parkinson's disease medications (including amantadine). Examples include an intense desire to gamble or to engage in risky sexual behavior. Let your healthcare provider know right away if you experience any of these urges.
  • People with Parkinson's disease have an increased risk for melanoma (a type of skin cancer). At this time, it is not clear if this is caused by Parkinson's disease medications (such as amantadine) or other factors. It is a good idea to have regular skin checks to monitor for this problem.
  • Amantadine can interact with a few different medications (see Drug Interactions With Amantadine).
  • Amantadine is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Symmetrel and Pregnancy).
  • Amantadine passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Symmetrel and Breastfeeding).
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Amantadine Hydrochloride (HCL)

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