Drug InteractionsAmantadine can interact with numerous other medications (see Drug Interactions With Amantadine).
What If I Take an Overdose of Amantadine?An overdose of amantadine can be quite dangerous -- even life-threatening. If you happen to take too much, seek immediate medical attention.
(Click Symmetrel Overdose for more information.)
How Should Amantadine Be Stored?Amantadine should be stored at room temperature, away from moisture and heat. Keep the drug in an airtight container.
Keep this and all other medications out of the reach of children.
What Should I Do If I Miss a Dose?If you miss a dose of amantadine, take the missed dose as soon as you remember and then continue with your regular schedule. However, if it is almost time for your next dose, skip the missed dose and continue as directed. Do not take a double dose.
How Does Amantadine Work?Amantadine may work for the flu by inhibiting the uncoating of the flu virus, an important step in the replication (the "reproduction") of the virus. Specifically, it inhibits the activity of the influenza virus M2 protein, which forms a channel in the virus membrane. As a result, the virus cannot replicate (make copies of itself) after it enters a human cell.
Amantadine is effective only for some influenza A viruses and is not effective against influenza B viruses. Because the "bird flu" or "avian flu" virus (H5N1) is a type of influenza A, the medication may work for some strains of this virus. However, many strains of H5N1 influenza are resistant to it.
For any given year, the predominant flu strain may or may not be susceptible to amantadine. If the predominant flu strain is not susceptible, this medication should not be used to prevent or treat the flu.
It is not known exactly how the medication works for Parkinson's disease and other similar conditions or movement disorders. Amantadine is known to affect several different brain chemicals, including dopamine and NMDA (N-methyl D-aspartate).