Amantadine Dosing (Cont.)

Amantadine Dosing for Parkinsonism

For treating parkinsonism (including Parkinson's disease), the recommended dose is amantadine 100 mg twice a day, if no other Parkinson's medications are used. If you have serious medical illnesses associated with Parkinson's disease, or if you take high doses of other Parkinson's disease medications, the recommended dose is amantadine 100 mg once daily. (After at least one week, your healthcare provider may increase the dose to 100 mg twice daily.)
 
In some cases, your healthcare provider may increase your dose up to a maximum of 400 mg total per day, if necessary.
 

Amantadine Dosing for Extrapyramidal Symptoms (EPS)

The recommended dose of amantadine for treating extrapyramidal symptoms (EPS) caused by other medications is amantadine 100 mg twice daily. If necessary, your healthcare provider may increase your dose up to a total of 300 mg per day.
 

General Information on Dosing With Amantadine

Some considerations for people taking amantadine include the following:
 
  • The medication comes in the form of a tablet and syrup (generic amantadine is also available as a capsule). It is usually taken by mouth once or twice a day.
     
  • You can take amantadine with or without food. If the medication bothers your stomach, try taking it with food.
     
  • If you have liver or kidney disease, your healthcare provider may recommend a low amantadine dose.
     
  • For the medication to work properly, it must be taken as prescribed. Amantadine will not work if you stop taking it or if you stop taking it too early.
     
  • If you are unsure about anything related to amantadine dosing, please talk to your doctor, nurse, or pharmacist.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;